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Short answer
What is SS-31?
SS-31, also called elamipretide, is a synthetic tetrapeptide (D-Arg-2,6-dimethyl-Tyr-Lys-Phe-NH2) that targets the inner mitochondrial membrane, where it binds cardiolipin.
It also appears in the literature as elamipretide, SS-31, MTP-131, Szeto-Schiller peptide, D-Arg-Dmt-Lys-Phe-NH2.
Read the full explainer: what is SS-31?What is in each SS-31 vial?
| STRENGTH | FORM | PRICE | CERTIFICATE |
|---|---|---|---|
| 10mg | Lyophilised powder | A$98 | Pending |
What has research on SS-31 examined?
Elamipretide has been studied in cell and animal models of mitochondrial dysfunction and in human randomised trials, including in Barth syndrome (TAZPOWER) and primary mitochondrial myopathy (MMPOWER-3). A 2026 review in Drugs reports its first regulatory approval.
The table lists primary sources by year and model. Findings describe the study subjects, not this research vial.
What adverse events have studies of SS-31 reported?
In a phase 3 randomised trial in 218 adults with primary mitochondrial myopathy (40 mg/day subcutaneous), the authors report that most adverse events were mild to moderate (PMID 37268435). In the Barth syndrome open-label extension (10 patients, up to 168 weeks), injection-site reactions were the most common adverse events (PMID 38602181).
These findings describe the people or animals in each study. The sources list gives every PubMed record.
How do you reconstitute and store SS-31?
Store the sealed vial frozen (about -20 degrees Celsius), dry and away from light until it is reconstituted.
After reconstitution with a sterile solvent, keep the solution at 2 to 8 degrees Celsius and avoid repeated freezing and thawing. Record the solvent, volume and date on the vial label.
BAC Water is the usual laboratory solvent. Dilute acetic acid is an alternative for peptides that dissolve poorly in water. The reconstitution guide and storage guide cover laboratory handling.
| STATE | TEMPERATURE | NOTES |
|---|---|---|
| Sealed vial | -20 °C | Dry and dark. Keeps to the label date. |
| Reconstituted | 2 to 8 °C | Sterile technique. Avoid repeat freeze and thaw. |
| In transit | Cold pack | Refrigerate or freeze on arrival. |
Is SS-31 legal to buy in Australia?
SS-31 is not named in the Poisons Standard (June 2026 instrument). Source: the June 2026 Poisons Standard instrument (F2026L00633).
SS-31 is not named on WADA's 2026 Prohibited List. WADA's S0 class covers any substance without government approval for human use, so Sport Integrity Australia is the body to confirm its status.
- POISONS STANDARD
- Not named
- WADA 2026
- Not named
- SALE TERMS
- Research use only
How fast does SS-31 ship?
Orders placed before [cut-off] leave Western Australia the same business day with tracking, by [carrier]. Delivery estimates for each state are on the shipping page.
SS-31 questions
What has research on SS-31 examined?
Elamipretide has been studied in cell and animal models of mitochondrial dysfunction and in human randomised trials, including in Barth syndrome (TAZPOWER) and primary mitochondrial myopathy (MMPOWER-3). A 2026 review in Drugs reports its first regulatory approval.
What adverse events have studies of SS-31 reported?
In a phase 3 randomised trial in 218 adults with primary mitochondrial myopathy (40 mg/day subcutaneous), the authors report that most adverse events were mild to moderate (PMID 37268435). In the Barth syndrome open-label extension (10 patients, up to 168 weeks), injection-site reactions were the most common adverse events (PMID 38602181).
Is SS-31 a peptide?
Yes. SS-31 is a peptide of 4 amino acids.
Is SS-31 a prescription medicine in Australia?
SS-31 is not named in the Poisons Standard (June 2026 instrument). Peptides Collective sells it for laboratory research use only.
Is SS-31 banned in sport?
SS-31 is not named on WADA's 2026 Prohibited List. WADA's S0 class covers any substance without government approval for human use, so Sport Integrity Australia is the body to confirm its status.
What is the CAS number for SS-31?
The CAS number for SS-31 is 736992-21-5. Its PubChem CID is 11764719.
How long does an unopened SS-31 vial keep?
A sealed vial of lyophilised powder keeps to the date on its label when stored frozen, dry and dark. Once reconstituted, keep the solution at 2 to 8 degrees Celsius and record the date on the label.
Does every SS-31 batch have a certificate?
Yes. Every SS-31 batch is tested by [lab] before it goes on sale, and the certificate is published under the batch number printed on the vial. The current batch certificate is [pending].
Where is SS-31 shipped from?
Orders ship tracked from Western Australia. Orders placed before [cut-off] leave the same business day. Delivery estimates by state are on the shipping page.
What purity is the current SS-31 batch?
The current SS-31 batch certificate is [pending]. When it is published, it reports purity by HPLC to three decimal places and confirms identity by mass spectrometry.
Which solvent reconstitutes SS-31?
BAC Water (sterile water with 0.9% benzyl alcohol) is the usual laboratory solvent. Dilute acetic acid is an alternative for peptides that dissolve poorly in water. Record the solvent, volume and resulting concentration on the vial label.
How much does SS-31 cost in Australia?
SS-31 costs A$98 for 10mg at Peptides Collective, in Australian dollars. Each price is per vial of lyophilised powder.
Sources
- 1. A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism. Genetics in medicine : official journal of the American College of Medical Genetics, 2021. PMID 33077895.
- 2. Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial. Neurology, 2023. PMID 37268435.
- 3. Stealth Peptides Target Cellular Powerhouses to Fight Rare and Common Age-Related Diseases. Protein and peptide letters, 2018. PMID 30381054.
- 4. Elamipretide: First Approval. Drugs, 2026. PMID 41335372.
- 5. Long-term efficacy and safety of elamipretide in patients with Barth syndrome: 168-week open-label extension results of TAZPOWER. 2024. PMID 38602181.
- 6. Elamipretide Topical Ophthalmic Solution for the Treatment of Subjects with Leber Hereditary Optic Neuropathy: A Randomized Trial. 2024. PMID 37923251.
- 7. PubChem CID 11764719. National Library of Medicine.
- 8. Poisons Standard, June 2026 instrument (F2026L00633). Federal Register of Legislation.
- 9. World Anti-Doping Code, 2026 Prohibited List. WADA.
