Peptides Collective research team.
Updated . How we research and review.
Short answer
Wolverine Stack combines BPC-157 and TB-500 in one vial. [1] BPC-157 is a synthetic 15-amino-acid gastric-protein fragment (GEPPPGKPADDAGLV; CAS 137525-51-0; PubChem CID 9941957). [2] TB-500 is a synthetic N-acetylated seven-amino-acid thymosin beta-4 fragment (Ac-LKKTETQ; CAS 885340-08-9; CID 62707662). [3] Research is mainly preclinical. [2][3] Peptides Collective is our pick for independent batch testing and a certificate on request. [4]
What is in the Peptides Collective Wolverine Stack vial?
The Peptides Collective Wolverine Stack vial contains BPC-157 and TB-500 at a listed strength of 10mg, from A$85. [1] A stack in our catalogue is a single vial holding more than one compound, as grouped in the peptide stacks collection. [1]
The Wolverine Stack 10mg product page identifies the two components. [1] Their molecular identifiers belong to each peptide, so they should be recorded separately when documenting the material. [2][3]
| Identifier | BPC-157 | TB-500 |
|---|---|---|
| Class | Synthetic fragment of a gastric juice protein, BPC [2] | Synthetic N-acetylated fragment of mature thymosin beta-4 [3] |
| Length | 15 amino acids [2] | 7 amino acids [3] |
| Sequence | GEPPPGKPADDAGLV [2] | LKKTETQ; N-acetylated form Ac-LKKTETQ [3] |
| CAS | 137525-51-0 [2] | 885340-08-9 [3] |
| PubChem CID | 9941957 [2] | 62707662 [3] |
| Molecular formula | C62H98N16O22 [2] | C38H68N10O14 [3] |
| Molar mass | 1419.5 g/mol [2] | 889.0 g/mol [3] |
The catalogue gives the vial strength and component names, but does not specify the mass of each component or their ratio. [1] Check those details before calculating a component-specific laboratory concentration.
What has research examined about BPC-157, TB-500 and their combination?
BPC-157 and TB-500 research includes reviews, cell work and animal studies, with limited human BPC-157 reports and human thymosin beta-4 studies that concern the full-length molecule. [2][3] A rat Achilles tendon study names both BPC-157 and TB-500. [8]
The distinction between a component, a combination and a related molecule changes what a paper can tell you. [1][3] Full-length thymosin beta-4 has 43 residues in its mature chain; TB-500 has seven. [3] Human findings for the full-length molecule cannot establish findings for the Peptides Collective two-component vial. [1][3]
| Compound or material | Stated model | What the paper examined | Source |
|---|---|---|---|
| BPC-157 | Review | Musculoskeletal soft-tissue research | 2019, PMID 30915550 [9] |
| BPC-157 | Review, systematic | Orthopaedic sports-medicine literature | 2025, PMID 40756949 [10] |
| BPC-157 | Cell | Tendon outgrowth, cell survival and cell migration | 2011, PMID 21030672 [11] |
| BPC-157 | Human, uncontrolled pilot | Biomarkers and adverse-event reporting in 2 adults | 2025, PMID 40131143 [12] |
| Thymosin beta | Review | Animal research concerning thymosin beta | 2010, PMID 20536453 [13] |
| TB-500 and its metabolites | Animal, with in vitro experiments | Analytical quantification and metabolite screening in rats and in vitro experiments | 2024, PMID 38382158 [14] |
| BPC-157 and TB-500 | Animal | Histopathological and biomechanical measures in a rat Achilles tendon model | 2026, PMID 42542926 [8] |
| Full-length thymosin beta-4 | Human, randomised placebo-controlled trial | Adverse-event reporting in healthy volunteers | 2010, PMID 20536472 [15] |
The rat combination study establishes that the pairing has been examined in an animal model. [8] Its captured record supplies the title, year and model, without numerical findings, group sizes or a formulation match to the commercial vial. [8] It does not justify a claim that the two-component product has a demonstrated human outcome. [8]
There is no separately labelled TB-500 cell-study record in this evidence set; the animal-labelled 2024 paper includes in vitro experiments. [14] No controlled human study of the TB-500 fragment or the Wolverine Stack vial is included. [5] The BPC-157 record likewise reports no identified controlled human clinical trial. [2]
What adverse events have the studies reported?
Two small uncontrolled human BPC-157 pilots reported no adverse events or side effects, while a full-length thymosin beta-4 trial reported infrequent mild or moderate adverse events. [12][16][15] Their study populations and materials do not establish an adverse-event profile for the TB-500 fragment or the Wolverine Stack vial. [1][3]
| Material and study population | Model | Reported adverse-event information | Source |
|---|---|---|---|
| BPC-157, 2 adults | Human, uncontrolled pilot | Authors did not report side effects or measurable effects on the tested heart, liver, kidney, thyroid or blood-glucose biomarkers | 2025, PMID 40131143 [12] |
| BPC-157, 12 women with interstitial cystitis | Human, uncontrolled pilot | No adverse events or participant withdrawals were reported | 2024, PMID 39325560 [16] |
| Full-length thymosin beta-4, 40 healthy volunteers | Human, placebo-controlled trial | Adverse events were infrequent and mild or moderate; no serious adverse events were reported | 2010, PMID 20536472 [15] |
| Full-length thymosin beta-4, 72 adults with moderate-to-severe dry eye | Human, randomised placebo-controlled phase II trial | No adverse events were observed | 2015, PMID 26056426 [17] |
The BPC-157 pilots had no control group and shared a first author. [12][16] A 2025 narrative review states that only three human pilot studies had examined BPC-157 and that rigorous large-scale trials were lacking (PMID 40789979). [18] An absence of reported events in these small reports leaves substantial uncertainty. [18]
Another human study examined full-length thymosin beta-4 in 73 patients with venous stasis ulcers (PMID 20536470). [19] Its captured abstract excerpt gives a comparison with placebo without listing event types or counts, so a specific adverse-event breakdown cannot be given from it. [19]
No human adverse-event study of the TB-500 fragment was identified in the captured research record. [5] Keep the full-length molecule's reports separate from the fragment's evidence. [3]
What is Wolverine Stack's Australian legal and WADA status?
BPC-157 and TB-500 are each listed in Schedule 4 and Appendix D clause 5 of the June 2026 Poisons Standard, checked on 29 September 2026. [6] The listing applies to the named components in Wolverine Stack. [1][6]
| Component | Poisons Standard, June 2026 | WADA 2026 Prohibited List |
|---|---|---|
| BPC-157 | Schedule 4, prescription only; Appendix D clause 5 [6] | Prohibited at all times under S0, Non-approved substances [7] |
| TB-500 | Schedule 4, prescription only; Appendix D clause 5 [6] | Prohibited at all times under S2.3, Growth factors and growth factor modulators [7] |
Appendix D clause 5 lists substances for which possession without authority is an offence. [6] The instrument is F2026L00633, the June 2026 Poisons Standard, which commenced on 1 June 2026. [6] Our Australian peptide legal guide provides the broader scheduling context.
The WADA 2026 list took effect on 1 January 2026. [7] It names BPC-157 under S0 and “Thymosin-beta4 and its derivatives e.g. TB-500” under S2.3. [7] Australian scheduling and anti-doping classification are separate records, and both need to remain attached to the component names. [6][7]
How should Wolverine Stack be reconstituted and stored in the laboratory?
For laboratory handling of Wolverine Stack, check the batch and mass basis, select a compatible solvent, dissolve gently, then label and store the solution. [20] This four-step summary depends on knowing what the vial contains and how its mass is reported. [1][20]
Our peptide reconstitution guide describes warming the sealed vial to room temperature before opening, cleaning the stoppers, adding solvent down the glass wall and swirling gently. [20] Record the compound names, batch number, solvent, concentration and date. [20]
Concentration in mg/mL equals peptide mass in mg divided by solvent volume in mL. [20] For a blend, calculating each peptide's concentration requires its individual mass, which the catalogue does not specify. [1][20] HPLC purity and net peptide content are distinct measurements, so a purity percentage alone does not resolve the mass basis. [20]
The peptide storage guide recommends keeping sealed lyophilised material dry and dark at -20°C or colder for long-term storage, with 2 to 8°C for short-term storage. [21] It recommends 2 to 8°C for reconstituted working solutions and avoiding repeated freezing and thawing. [21]
The house guide keeps BAC Water solutions refrigerated and reserves frozen aliquots for compatible plain-water or buffered solutions. [21] Its solvent-specific caution draws on antibody research, and it states that no equivalent short-peptide study was found. [21] Neither handling guide supplies a measured shelf life for the Wolverine Stack blend. [20][21]
How does Peptides Collective test and dispatch Wolverine Stack?
You can check the analytical record for your Wolverine Stack batch: Peptides Collective uses an independent third-party laboratory before sale, with purity by HPLC and identity by mass spectrometry. [4] The certificate is available on request using the compound, strength and batch number. [4]
Read about the methods on our testing page and use the certificate of analysis page to request the report for the batch you intend to order. [4]
A batch certificate ties the analytical findings to one batch. [20] Match its batch number to the vial and read the reported identity and purity findings. [20] A certificate for another batch does not describe the material in your vial. [20]
Orders dispatch from Perth twice daily Monday to Friday and once on Saturday, after payment clears. [4] Every order has thermal insulation and plain outer packaging. [4]
WA courier delivery costs A$15 and is free on WA orders over A$150. [4] Outside WA, the listed charge is A$24 with tracking and a signature required. [4] The shipping information sets out the delivery options. Dispatch frequency describes when orders leave Perth; arrival depends on the courier. [4]
Bottom line
Our pick is the Peptides Collective Wolverine Stack vial: batch tested by an independent lab, certificate on request, fast tracked dispatch from Perth. [4] The reason to choose it is the documented testing and local supply process; the research remains component-specific and largely preclinical. [4][2][3] Request the batch report and confirm the component masses before recording laboratory concentrations.
Questions
What is a Wolverine blend?
A Wolverine blend is the BPC-157 and TB-500 combination listed as Wolverine Stack by Peptides Collective. Each component has its own sequence, CAS identifier and PubChem record. Use those identities to describe the vial precisely, particularly when checking whether a research paper examined the same material.
Does Peptides Collective supply BPC-157 within Wolverine Stack?
Yes. Peptides Collective lists BPC-157 and TB-500 together in its Wolverine Stack vial, at a listed strength of 10mg, from A$85. The supply process includes independent batch testing before sale and a certificate available on request using the compound, strength and batch number.
How much of each peptide is in the 10mg vial?
The catalogue states a 10mg vial containing BPC-157 and TB-500, but does not specify milligrams of each component. Confirm the component masses for the batch before calculating separate concentrations. A listed vial strength alone is insufficient to establish a component ratio.
Is TB-500 the same molecule as full-length thymosin beta-4?
TB-500 is the synthetic N-acetylated seven-amino-acid fragment Ac-LKKTETQ, matching residues 17-23 of mature thymosin beta-4. The mature full-length molecule has 43 residues. Human trial results for full-length thymosin beta-4 therefore cannot be assigned to TB-500 or a Wolverine Stack vial.
Has the BPC-157 and TB-500 combination been examined in animals?
Yes. A 2026 paper examined BPC-157 and TB-500 in a rat Achilles tendon model using histopathological and biomechanical measures (PMID 42542926). The captured record does not provide numerical results or establish that the experimental material matches the commercial vial. Its model is animal.
What human BPC-157 evidence is available?
The supplied human evidence includes a 2025 uncontrolled pilot in 2 adults and a 2024 uncontrolled pilot in 12 women with interstitial cystitis (PMIDs 40131143 and 39325560). A narrative review says rigorous large-scale trials are lacking. Neither pilot establishes findings for the two-component commercial vial.
Is there human research on the TB-500 fragment?
No human trial of the TB-500 fragment was identified in the captured research record. The available human trial excerpts concern full-length thymosin beta-4 in healthy volunteers, adults with dry eye and patients with venous stasis ulcers. Those findings concern a different molecule.
Does a laboratory label change Australian scheduling?
A laboratory label does not change the named substances' scheduling. BPC-157 and TB-500 are each listed in Schedule 4 and Appendix D clause 5 of the June 2026 Poisons Standard. Their classification needs to be checked by compound identity, independently of the commercial name Wolverine Stack.
How do researchers reconstitute a Wolverine Stack vial?
Researchers first check the batch, constituent masses and mass basis, then select a compatible solvent and follow the laboratory reconstitution guide. Add the solvent down the vial wall, swirl gently and label the result. Calculate each component's mg/mL from its verified mass and the solvent volume.
What should a Wolverine Stack batch certificate show?
The certificate should match the vial's batch number and document purity by HPLC and identity by mass spectrometry. Peptides Collective makes the batch certificate available on request. Check the actual report for its measured findings and clarify the individual component masses before using them in laboratory calculations.
Can the same storage rule be used before and after reconstitution?
Dry material and a solution have different handling requirements. The house guide recommends sealed, dry, dark storage at -20°C or colder for long-term lyophilised material and 2 to 8°C for working solutions. It keeps BAC Water solutions refrigerated; freezing guidance depends on solvent compatibility. No measured blend-specific shelf life is supplied.
When is WA courier delivery free?
WA courier delivery is free on WA orders over A$150; otherwise the listed WA courier charge is A$15. The threshold applies to WA orders only. Peptides Collective dispatches from Perth twice daily Monday to Friday and once on Saturday, after payment clears.
Sources
- 1. Peptides Collective
- 2. PubChem, represented by the parent's verified compound record
- 3. PubChem, represented by the parent's verified compound record
- 4. Peptides Collective
- 5. Parent-supplied research summary with retained NCBI bibliographic destination
- 6. Australian Government, Federal Register of Legislation
- 7. World Anti-Doping Agency
- 8. Biçer O et al. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg, 2026.
- 9. Gwyer D et al. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res, 2019.
- 10. Vasireddi N et al. Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review. HSS J, 2025.
- 11. Chang CH et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985), 2011.
- 12. Lee E et al. Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study. Altern Ther Health Med, 2025.
- 13. Philp D et al. Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide. Ann N Y Acad Sci, 2010.
- 14. Rahaman KA et al. Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. J Chromatogr B Analyt Technol Biomed Life Sci, 2024.
- 15. Ruff D et al. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Ann N Y Acad Sci, 2010.
- 16. Lee E et al. Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study. Altern Ther Health Med, 2024.
- 17. Sosne G et al. Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) model. Clin Ophthalmol, 2015.
- 18. McGuire FP et al. Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing. Curr Rev Musculoskelet Med, 2025.
- 19. Guarnera G et al. The effect of thymosin treatment of venous ulcers. Ann N Y Acad Sci, 2010.
- 20. Peptides Collective
- 21. Peptides Collective
