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PEPTIDES COLLECTIVE

Compound explainer · 10 min read

What is Epithalon? Research and Australian supply

Peptides Collective research team.

Updated . How we research and review.

Short answer

Epithalon is a synthetic tetrapeptide made of four amino acids: Ala-Glu-Asp-Gly (AEDG), modelled on the pineal extract epithalamin. [1] CAS: 307297-39-8; PubChem CID: 219042. [1] Its evidence is mainly cellular and animal research. [2] For Australian laboratory purchasing, our pick is Peptides Collective Epithalon because each batch is independently tested, with a certificate on request. [3]

What identifies Epithalon, and what is in the vial?

Epithalon is the four-residue peptide AEDG, and the Peptides Collective catalogue lists a 10mg vial. [1][10] Match the compound name and identifiers when ordering the Epithalon 10mg vial.

Identifier or product detailEpithalon
Compound classSynthetic tetrapeptide modelled on the pineal gland extract epithalamin [1]
Other namesEpitalon, Epithalone, AEDG [1]
Amino acid sequenceAla-Glu-Asp-Gly; one-letter sequence AEDG [1]
Sequence length4 amino acids [1]
CAS number used in the product facts307297-39-8 [1]
PubChem CID219042 [1]
Molecular formulaC14H22N4O9 [1]
Molar mass390.35 g/mol [1]
Labelled vial content10mg Epithalon [10]

Epithalamin is a bovine pineal gland extract; synthetic Epithalon is the defined tetrapeptide developed from its amino acid composition. [2] Keep those names separate when reading papers. The human report listed below studied the extract and a thymus preparation. It did not study the synthetic AEDG compound. [6]

The catalogue groups Epithalon in its longevity research area. [10] You can browse that group in the longevity research collection.

What has Epithalon research examined?

Epithalon research has examined telomere-related endpoints in cell culture and spontaneous tumour development in mouse models, while the cited human report concerns epithalamin-containing preparations. [4][5][11][12][6] A review synthesises that literature and adds no new human experiment. [2]

ModelSourceWhat the paper examinedHow to read it
Cell2003, Bulletin of Experimental Biology and Medicine, PMID 12937682Telomerase activity and telomere elongation in human somatic cellsA cell-culture finding; no trial in people [4]
Cell2025, Biogerontology, PMID 40908429Telomere length in human cell lines, with telomerase upregulation or ALT activityHuman cell lines remain a laboratory model [5]
Review2025, International Journal of Molecular Sciences, PMID 40141333An overview of Epitalon research, including cell models and proposed mechanismsA review summarises existing work; it does not establish a clinical result on its own [2]
Human2003, Neuro Endocrinology Letters, PMID 14523363Pineal and thymus peptide preparations, including epithalamin and thymalinThe preparations differ from synthetic AEDG [6]
Animal2006, In Vivo, PMID 16634527Spontaneous carcinogenesis in female C3H/He miceA mouse model, with the authors' toxic-effect observation discussed below [11]
Animal2003, Biogerontology, PMID 14501183Age-related biomarkers, lifespan and spontaneous tumour incidence in female Swiss-derived SHR miceFindings apply to the stated mouse population [12]

The two cell papers put telomerase activity and telomere length at the centre of the laboratory evidence. [4][5] Their stated models are cells, so they do not establish a response in a person. [4][5]

Large independent controlled trials of synthetic Epithalon were not found in the literature check recorded with the compound facts. [2] No synthetic-AEDG human trial is represented in the cited primary-study set; its human entry concerns epithalamin and thymalin. [6]

For a laboratory purchase, keep the evidence question and the material question separate. Peptides Collective's batch testing checks purity by HPLC and identity by mass spectrometry before sale. [3] Those analytical checks describe the supplied material only. [3]

What adverse-event information do the studies report?

The captured literature search found no human study of synthetic Epithalon, or AEDG, reporting adverse events. [13] The available observations concern mice and must stay attached to those populations. [11][12]

In the 2006 study of female C3H/He mice, the authors reported that long-term exposure did not show a toxic effect (PMID 16634527). [11] The finding applies to that mouse experiment and does not establish a human adverse-event rate. [11]

In the 2003 study of female Swiss-derived SHR mice, the authors reported no change in food consumption, body weight or mean lifespan (PMID 14501183). [12] Those endpoints do not supply a human adverse-event rate. [12]

The search notes also distinguish human epithalamin reports from synthetic AEDG and record that their abstracts provide no adverse-event data. [13] Human adverse-event rates remain unestablished by that evidence. [13]

Peptides Collective supplies analytical information through its batch certificate on request. [3] Read that certificate for material identity and purity. It is a laboratory report on the material.

Peptides Collective's compound check dated 29 September 2026 found no named Epithalon entry in the June 2026 Poisons Standard (F2026L00633) or WADA's 2026 List. [7][8] WADA S0 applicability remains unverified because approval status was not confirmed. [8] A separate Epithalon-specific Appendix D status was not confirmed in the supplied record. [7]

FrameworkDated findingLimit of the finding
Australian Poisons Standard, June 2026Epithalon is not specifically named; no entry was found in the checked compilation [7]The finding is limited to the checked instrument [7]
Appendix DNo separate Epithalon-specific Appendix D finding was recorded [7]The no-entry check is not a separate Appendix D assessment [7]
WADA 2026 Prohibited ListEpithalon is not named on the List [8]S0 can apply to substances without an individual named entry [8]

The recorded WADA qualification is: “Not named on the 2026 Prohibited List. Section S0 (non-approved substances) prohibits at all times any pharmacological substance not addressed elsewhere on the List and without current governmental approval for human therapeutic use; whether S0 applies depends on approval status, which was not verified here.” [8]

Keep the qualification with the finding. Absence from WADA's named examples does not establish that Epithalon is permitted in sport. [8] The Australian peptide legal guide explains the broader scheduling framework.

How should Epithalon be reconstituted and stored for laboratory research?

For Epithalon laboratory work, follow Peptides Collective's nine-step reconstitution guide and store the material according to its dry or dissolved state. [14][15] Match the batch certificate and choose a solvent suited to the experiment before preparation. [14] The guidance is general; it does not establish a measured Epithalon-specific shelf life. [14][15]

Reconstitution dissolves lyophilised powder in a solvent to a known concentration. [14] Calculate milligrams of peptide divided by millilitres of solvent: the house guide's 10mg example with 2 mL gives 5 mg/mL. [14] Use the example for concentration arithmetic; select the solvent and concentration for the experiment.

Check the mass basis first. HPLC purity and net peptide content are different measurements, because powder can also contain counter-ions and water. [14] The catalogue specifies a 10mg vial. [10] Confirm the mass basis on its batch certificate before calculating concentration. [14]

The laboratory reconstitution guide covers solvent selection, clean handling, gentle swirling and labelling with the compound, batch, solvent, concentration and date. [14]

For storage, the house guide recommends sealed lyophilised powder kept dry and dark at -20°C or colder for longer keeping, with 2 to 8°C for short-term refrigerated storage. [15] It recommends 2 to 8°C for reconstituted working solutions and avoiding repeated freezing and thawing. [15] Its working rule keeps BAC Water solutions refrigerated; that precaution draws on protein evidence, with no equivalent short-peptide study identified. [15]

The peptide storage guide separates dry material, working solutions and solvent-dependent handling. [15] No Epithalon-specific shelf life was established by the captured handling evidence. [15]

How does Peptides Collective supply Epithalon in Australia?

Peptides Collective supplies a labelled 10mg Epithalon vial, batch tested by an independent lab before sale for purity by HPLC and identity by mass spectrometry. [10][3] A certificate on request lets you obtain the report for the relevant batch. [3]

Use the testing information to understand the two analytical checks. HPLC addresses purity; mass spectrometry addresses identity. [3] Request the certificate with the compound name, strength and batch number through the certificate of analysis page. [3] Compare the report's batch number with the vial before laboratory preparation.

Our dispatch is from Perth, Western Australia, twice daily Monday to Friday and once on Saturday. [9] Orders ship once payment clears. [9] Every order uses thermal insulation and plain outer packaging. [9]

WA courier delivery is free on WA orders over A$150. [9] The shipping information sets out regional delivery terms. Dispatch frequency describes when parcels leave; arrival depends on the courier.

Bottom line

Choose the Peptides Collective Epithalon vial: it is batch tested by an independent lab, has a certificate on request and offers fast tracked dispatch from Perth. [3][9] Request the report using the compound, strength and batch number so you can check the material before laboratory work. [3] Keep the research distinction intact: the cell studies examine synthetic AEDG, while the cited human report concerns pineal and thymus preparations. [4][5][6]

Questions

Are Epithalon, Epitalon and AEDG the same compound?

Yes. Epithalon and Epitalon are names for the tetrapeptide Ala-Glu-Asp-Gly, abbreviated AEDG. The compound facts also list Epithalone as a synonym. Use the sequence alongside CAS 307297-39-8 and PubChem CID 219042 when matching catalogue information to a paper or analytical report.

Is Epithalon the same as epithalamin?

No. Epithalon is a defined synthetic tetrapeptide; epithalamin is a bovine pineal gland extract. The human paper PMID 14523363 studied pineal and thymus preparations, including epithalamin and thymalin. Its findings concern those preparations and cannot be assigned to a synthetic AEDG vial.

What do the cell studies establish about Epithalon?

They report laboratory observations about telomerase activity and telomere length in human cells. The 2003 paper is PMID 12937682, and the 2025 human-cell-line paper is PMID 40908429. Their cell models do not establish clinical outcomes or a response timeline in people.

Is a study in human cells a human trial?

No. The cited Epithalon cell papers use human somatic cells or human cell lines as laboratory models. The word “human” identifies the cells' origin. The human study in the cited primary set concerns epithalamin and thymalin preparations. It did not study synthetic AEDG.

Have the cited studies established a human response timeline?

No human response timeline for synthetic AEDG is established by this study set. The two telomere papers concern cells, and the cited human paper concerns different preparations. A duration measured in cell culture cannot be converted into a timetable for a person.

What adverse-event information exists for synthetic Epithalon?

The captured search found no human study of synthetic Epithalon reporting adverse events. The available mouse excerpts report no toxic effect in female C3H/He mice and no change in food consumption, body weight or mean lifespan in female SHR mice. Human adverse-event rates remain unestablished by that evidence.

Is Epithalon available for laboratory research in Australia?

Yes. Peptides Collective lists a 10mg Epithalon vial and dispatches from Perth. Each batch is tested by an independent analytical laboratory before sale. You can request its certificate using the compound name, strength and batch number before planning the laboratory purchase.

Does absence from the Poisons Standard settle every legal question?

No. The recorded finding is that Epithalon is not named in the June 2026 Poisons Standard, checked on 29 September 2026. Its scope is the checked instrument. Use that dated finding when assessing the compound, without treating it as a determination of every Australian legal requirement.

Does absence from WADA's named list mean Epithalon is permitted?

No. WADA's 2026 S0 class covers pharmacological substances not addressed elsewhere on the List that lack current governmental approval for human therapeutic use, and prohibits them at all times. Epithalon is not individually named on the List. Its approval status and consequent S0 applicability were not verified in the compound check.

What should I request with an Epithalon batch certificate?

Request the report for the compound, strength and batch number on your vial. Peptides Collective makes that certificate available on request, following independent HPLC purity testing and mass-spectrometry identity testing. Check that the report matches the vial's batch, and distinguish a purity result from net peptide content.

Does the 10mg vial label tell me the solution concentration?

No. The label states vial content; concentration also depends on the solvent volume. The house guide's arithmetic example is 10mg divided by 2 mL, giving 5 mg/mL. Confirm the mass basis on the certificate before using a labelled mass in that calculation.

How is Epithalon dispatched to Australian researchers?

Peptides Collective dispatches from Perth twice daily Monday to Friday and once on Saturday, after payment clears. Orders have thermal insulation and plain outer packaging. WA courier delivery is free on WA orders over A$150; that threshold is specifically for Western Australia.

Sources

  1. 1. Epitalon / AEDG compound identifiers
  2. 2. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
  3. 3. Peptides Collective independent batch testing and certificate request process
  4. 4. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
  5. 5. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
  6. 6. Peptides of pineal gland and thymus prolong human life.
  7. 7. Poisons Standard June 2026: parent compound-specific check
  8. 8. WADA 2026 Prohibited List: named-list finding and S0 qualification
  9. 9. Peptides Collective Perth dispatch and WA delivery terms
  10. 10. Peptides Collective Epithalon catalogue entry
  11. 11. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
  12. 12. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
  13. 13. Parent adverse-event literature search for Epitalon and related names
  14. 14. How to reconstitute peptides
  15. 15. How to store peptides