Peptides Collective research team.
Updated . How we research and review.
Short answer
DSIP (delta sleep-inducing peptide) is a nine-amino-acid nonapeptide with sequence WAGGDASGE, CAS 62568-57-4 and PubChem CID 68816. [1][2] It was originally isolated from rabbit blood during induced sleep. [1] Research includes small human sleep studies; a 2006 review described its physiological role and receptor as unresolved. [3] For Australian laboratory supply, our pick is Peptides Collective DSIP: independent batch testing and a certificate on request. [4]
What identifies DSIP and what is in the vial?
Peptides Collective supplies DSIP as a single-compound 10mg vial, from A$78. [5] The DSIP 10mg product pairs that catalogue specification with independent batch testing and a certificate available on request. [5][4]
| Identifier or product detail | DSIP |
|---|---|
| Full name | Delta sleep-inducing peptide. [1] |
| Class | Nonapeptide originally isolated from rabbit blood during induced sleep. [1] |
| Synonym | Emideltide. [1] |
| Amino-acid sequence | WAGGDASGE. [1] |
| Expanded sequence | H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH. [1] |
| Length | 9 amino acids. [1] |
| CAS | 62568-57-4. [2] |
| PubChem CID | 68816. [1] |
| Molecular formula | C35H48N10O15. [8] |
| Molar mass | 848.8 g/mol. [8] |
| Peptides Collective vial | DSIP 10mg, from A$78. [5] |
The sequence and identifiers describe the compound; the certificate records analytical findings for the batch. [1][4] For laboratory concentration calculations, check whether the stated mass represents net peptide content or total powder, because the two can differ. [9]
What has DSIP research examined?
The captured DSIP research covers animal characterisation, human sleep studies and a review of its unresolved biological role. [6][3] Cell: no cell-culture study is included in this captured study set. [6]
| Model | Study | What the captured evidence establishes |
|---|---|---|
| Animal | 1978, PMID 568769 | Examined amino-acid analysis, sequence, synthesis and activity of the nonapeptide in an animal model. [10] |
| Human | 1987, PMID 3622582 | Examined 24-hour sleep-wake behaviour in severe chronic insomnia, with 14 participants recorded in the abstract-data note. [11][12] |
| Human | 1992, PMID 1299794 | Examined sleep in chronic insomnia in a double-blind study, with 16 participants recorded in the abstract-data note. [13][12] |
| Review | 2006, PMID 16539679 | Reviewed DSIP literature and described its physiological role and receptor as still unresolved. [3] |
The two insomnia records establish what researchers investigated, but the supplied study summaries contain no numerical efficacy results for those studies. [13][11] Their titles alone cannot establish the size or consistency of an effect. [13][11] The 2006 review also leaves a limit on mechanistic explanations: it describes the physiological role and receptor as unresolved. [3]
A separate 1981 human study of six middle-aged participants with chronic insomnia, PMID 7028502, reported longer sleep duration, fewer interruptions and slightly more REM sleep. [14] These are the abstract's observations in that small group. [14] The other captured human records examine sleep in six healthy volunteers and withdrawal in 107 inpatients. [15][16]
DSIP sits in Peptides Collective's cognitive research collection. [5] The analytical evidence available for the supplied vial is batch testing for purity and identity, with the certificate on request. [4] Those checks answer a material-quality question separately from the historical studies' biological questions. [4][6]
What adverse events have DSIP studies reported?
Headaches were reported by a few participants in a 1984 uncontrolled DSIP study of 107 inpatients with alcohol or opiate withdrawal. [16] The excerpt gives no exact headache count, so it does not support an event percentage. [16]
| Model and population | Source | Adverse-event reporting |
|---|---|---|
| Human, uncontrolled study: 107 inpatients, including 47 with alcohol withdrawal and 60 with opiate withdrawal | 1984, PMID 6548969 | A few patients reported headaches, without an exact count in the captured excerpt. [16] |
| Human, double-blind crossover: 6 healthy volunteers | 1981, PMID 6895513 | The abstract records no observed psychological, physiological or biochemical adverse effects in this small group. [15] |
| Human: 6 middle-aged participants with chronic insomnia | 1981, PMID 7028502 | The abstract records no daytime sedation or other adverse effects in these participants. [14] |
| Human: 16 participants with chronic insomnia | 1992, PMID 1299794 | No adverse-event data in the abstract, according to the verified abstract-data note. [12] |
| Human: 14 participants with severe chronic insomnia | 1987, PMID 3622582 | No adverse-event data in the abstract, according to the verified abstract-data note. [12] |
The observations from the two groups of six remain findings about those two groups only. They do not establish general safety. [15][14] An abstract without adverse-event data also leaves the event history unconfirmed. [12]
Peptides Collective's independent HPLC and mass spectrometry tests address batch purity and identity. [4] They do not answer the clinical questions left open by these small historical studies. [4][15][14]
What is DSIP's Australian legal and WADA status?
DSIP is not specifically named in the Poisons Standard (June 2026), according to the compound check verified on 29 September 2026. [17] The recorded finding is: “Not specifically named in the Poisons Standard (June 2026); no entry found in the current compilation.” [17] No DSIP-specific Schedule 4 or Appendix D listing was identified in that check. [17]
The named-entry finding concerns the June 2026 instrument and does not establish permission for every form of supply or use. [17] For broader scheduling context, read the Australian peptide law guide.
The WADA 2026 finding carries a separate qualification: “Not named on the 2026 Prohibited List. Section S0 (non-approved substances) prohibits at all times any pharmacological substance not addressed elsewhere on the List and without current governmental approval for human therapeutic use; whether S0 applies depends on approval status, which was not verified here.” [18]
Being unnamed on the List does not establish permission in sport, because S0 also defines a class through its approval-status conditions. [18] A definitive DSIP-specific S0 conclusion is not established by the supplied check. [18]
A Peptides Collective batch certificate provides analytical information about the material; the Poisons Standard and WADA checks answer separate regulatory questions. [4][17][18]
How should DSIP be reconstituted and stored for laboratory research?
For laboratory work with lyophilised DSIP, reconstitution means dissolving the peptide in a suitable sterile solvent at a known concentration. [9] Our general handling guidance reduces the process to four checks: confirm the batch and mass basis, prepare the vial, measure and add solvent, then label and store the solution. [9]
- Confirm the vial's batch number against the requested certificate and check the mass basis before calculating concentration. [4][9]
- Let the sealed vial reach room temperature before opening, then clean the stoppers and allow them to dry. [9]
- Measure the solvent volume, add it down the glass wall and swirl gently. [9] Select the solvent for the laboratory method. [9]
- Record the compound, batch number, solvent, concentration and date, then apply the relevant storage conditions. [9][19]
Concentration in mg/mL equals peptide mass in milligrams divided by solvent volume in millilitres. [9] The house guide's arithmetic example is 10mg in 2 mL, giving 5 mg/mL. [9] It illustrates the calculation only. DSIP has no verified solubility limit or measured batch concentration in our records. [9] Read the laboratory reconstitution guide for the solvent and mass-basis checks.
For dry, sealed peptide, our general storage guidance is dark and dry at -20°C or colder for long-term keeping, with 2 to 8°C for short-term storage. [19] Reconstituted working solutions are kept at 2 to 8°C and labelled with their preparation details. [19]
The solvent matters when considering frozen storage: the house working rule keeps BAC Water solutions refrigerated and limits frozen aliquots to peptide in plain sterile water or buffer. [19] Avoid repeated freezing and thawing. [19] Follow the solvent distinctions in the peptide storage guide.
No DSIP-specific stability experiment or validated post-reconstitution shelf life is supplied in the captured handling evidence. [9][19] The general opened preserved-vial rule of 28 days unless the manufacturer states another date concerns vial management; it does not establish DSIP's chemical stability for that period. [19]
How does Peptides Collective test and dispatch DSIP?
Peptides Collective supplies DSIP with independent batch testing for purity by HPLC and identity by mass spectrometry, and makes the certificate available on request. [4] You can request the report using the compound name, strength and batch number. [4]
The testing process explains the analytical checks; the certificate of analysis information is the relevant reference when requesting a batch report. [4] Check that the report identifies the DSIP batch, then read its measured purity and identity findings. [4][9]
Tracked dispatch leaves Perth, Western Australia, twice daily Monday to Friday and once on Saturday. [7] Orders ship once payment clears, with thermal insulation and plain outer packaging. [7]
WA courier costs A$15 and is free on WA orders over A$150. [7] Outside WA, delivery is A$24 flat, tracked and signature required. [7] The Australian shipping terms distinguish the delivery options from the dispatch schedule. [7]
Bottom line
Choose Peptides Collective DSIP for independent batch testing and a certificate you can request for the vial's batch. [4] The DSIP product page lists the 10mg vial from A$78. [5] Tracked Perth dispatch runs twice daily Monday to Friday and once on Saturday, with free WA courier on WA orders over A$150. [7]
Questions
What does DSIP stand for?
DSIP stands for delta sleep-inducing peptide. It is a nonapeptide, meaning it has nine amino acids, with the sequence WAGGDASGE. Its name comes from early research involving rabbit blood during induced sleep; the later 2006 review still described its physiological role and receptor as unresolved.
Is emideltide another name for DSIP?
Yes, emideltide is listed as a DSIP synonym in the verified compound record. The record also gives the expanded sequence H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH. For identifying the compound in research records, the assigned catalogue references are CAS 62568-57-4 and PubChem CID 68816.
What do human DSIP sleep studies establish?
Human DSIP studies have examined sleep in chronic insomnia, including a 1992 double-blind study and a 1987 study of 24-hour sleep-wake behaviour. A separate 1981 human study reported longer sleep duration and fewer interruptions in six middle-aged participants with chronic insomnia. The captured summaries provide no numerical efficacy results for the two later studies and no basis for a general clinical outcome.
Is a specific DSIP receptor established by the captured research?
The captured 2006 review describes DSIP's receptor and physiological role as still unresolved. That is the dated review finding; later publications were not reassessed. A detailed receptor mechanism cannot be established from the study summaries supplied for this overview.
Are cell-culture studies included in this DSIP overview?
No cell-culture study is captured in the primary-study set used for this overview. The set includes an animal study, human sleep studies and a review; the additional adverse-event excerpts concern human populations. This evidence limit does not establish that cell studies are absent from the wider literature.
Which population reported headaches in a DSIP study?
A few participants reported headaches in the 1984 uncontrolled study of 107 inpatients with alcohol or opiate withdrawal, PMID 6548969. The population included 47 alcohol-withdrawal and 60 opiate-withdrawal inpatients. The captured excerpt gives no exact headache count, so a percentage cannot be calculated from it.
Do the captured studies establish a standard DSIP onset time?
No general onset time is established by the supplied study summaries. The 1987 human study examines 24-hour sleep-wake behaviour, while the 1981 human study excerpt reports sleep observations in six participants with chronic insomnia. Neither captured passage establishes a standard onset time applicable to other populations or conditions.
How much does the Peptides Collective DSIP vial cost?
Peptides Collective DSIP is listed from A$78 for the 10mg vial. Each batch is tested by an independent laboratory for purity by HPLC and identity by mass spectrometry, and the certificate is available on request. Shipping follows the stated regional terms, including free WA courier on WA orders over A$150.
Is DSIP named in Australia's Poisons Standard?
DSIP is not specifically named in the June 2026 Poisons Standard according to the check verified on 29 September 2026. No DSIP-specific schedule or Appendix D listing was identified in that check. The finding is limited to named entries and does not establish blanket permission under all Australian laws.
Does being unnamed on WADA's list establish permission in sport?
No, because the 2026 List's S0 class also prohibits pharmacological substances meeting its non-approved-substance conditions. DSIP is not named on the List. Whether S0 applies depends on governmental approval status, which the supplied check did not verify. The absence of a named entry therefore does not settle DSIP's status for sport.
What should I request for a Peptides Collective DSIP batch?
Request the certificate of analysis using the compound name DSIP, the 10mg strength and the batch number printed on the vial. Peptides Collective's stated testing covers purity by HPLC and identity by mass spectrometry. Check the report's batch match and mass basis before using the vial specification in laboratory concentration calculations.
What is known about DSIP storage duration after reconstitution?
No DSIP-specific post-reconstitution shelf life is established by the captured handling evidence. The house guide keeps working solutions at 2 to 8°C and distinguishes storage conditions by solvent. Its 28-day rule for opened preserved vials, unless the manufacturer states another date, does not validate DSIP's chemical stability for 28 days.
Sources
- 1. PubChem, National Library of Medicine
- 2. PubChem, National Library of Medicine
- 3. Kovalzon VM et al. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem, 2006.
- 4. Peptides Collective
- 5. Peptides Collective
- 6. PubMed, National Library of Medicine
- 7. Peptides Collective
- 8. PubChem, National Library of Medicine
- 9. Peptides Collective
- 10. Schoenenberger GA et al. The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. Pflugers Arch, 1978.
- 11. Schneider-Helmert D et al. Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia. Eur Neurol, 1987.
- 12. Bes F et al. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology, 1992.
- 13. Bes F et al. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology, 1992.
- 14. Schneider-Helmert D et al. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia, 1981.
- 15. Schneider-Helmert D et al. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. Int J Clin Pharmacol Ther Toxicol, 1981.
- 16. Dick P et al. DSIP in the treatment of withdrawal syndromes from alcohol and opiates. Eur Neurol, 1984.
- 17. Australian Federal Register of Legislation
- 18. World Anti-Doping Agency
- 19. Peptides Collective
