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Short answer
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, which makes it a mitochondrial-derived peptide.
It also appears in the literature as Mitochondrial open reading frame of the 12S rRNA-c, Mitochondria-derived peptide MOTS-c.
Read the full explainer: what is MOTS-c?What is in each MOTS-c vial?
| STRENGTH | FORM | PRICE | CERTIFICATE |
|---|---|---|---|
| 10mg | Lyophilised powder | A$78 | Pending |
What has research on MOTS-c examined?
MOTS-c has been examined mainly in cell and mouse models of metabolism, ageing and injury, beginning with a 2015 Cell Metabolism report. Human studies found on PubMed measure circulating endogenous MOTS-c (e.g. around exercise); no controlled trials giving MOTS-c to people were identified.
The table lists primary sources by year and model. Findings describe the study subjects, not this research vial.
What adverse events have studies of MOTS-c reported?
No study reporting adverse events from MOTS-c administration was found. Human studies in PubMed measure natural blood levels of MOTS-c (for example after exercise). Studies that give MOTS-c are in rodents and cells, and their abstracts do not report adverse events.
These findings describe the people or animals in each study. The sources list gives every PubMed record.
How do you reconstitute and store MOTS-c?
Store the sealed vial frozen (about -20 degrees Celsius), dry and away from light until it is reconstituted.
After reconstitution with a sterile solvent, keep the solution at 2 to 8 degrees Celsius and avoid repeated freezing and thawing. Record the solvent, volume and date on the vial label.
BAC Water is the usual laboratory solvent. Dilute acetic acid is an alternative for peptides that dissolve poorly in water. The reconstitution guide and storage guide cover laboratory handling.
| STATE | TEMPERATURE | NOTES |
|---|---|---|
| Sealed vial | -20 °C | Dry and dark. Keeps to the label date. |
| Reconstituted | 2 to 8 °C | Sterile technique. Avoid repeat freeze and thaw. |
| In transit | Cold pack | Refrigerate or freeze on arrival. |
Is MOTS-c legal to buy in Australia?
MOTS-c is not named in the Poisons Standard (June 2026 instrument). Source: the June 2026 Poisons Standard instrument (F2026L00633).
WADA's 2026 Prohibited List prohibits MOTS-c at all times, under class S4.4.1.
- POISONS STANDARD
- Not named
- WADA 2026
- Prohibited (S4.4.1)
- SALE TERMS
- Research use only
How fast does MOTS-c ship?
Orders placed before [cut-off] leave Western Australia the same business day with tracking, by [carrier]. Delivery estimates for each state are on the shipping page.
MOTS-c questions
What has research on MOTS-c examined?
MOTS-c has been examined mainly in cell and mouse models of metabolism, ageing and injury, beginning with a 2015 Cell Metabolism report. Human studies found on PubMed measure circulating endogenous MOTS-c (e.g. around exercise); no controlled trials giving MOTS-c to people were identified.
Is MOTS-c available in Australia?
Yes. Peptides Collective sells MOTS-c in Australia for laboratory research use only, at A$78 for 10mg, with a certificate for every batch. MOTS-c is not named in the Poisons Standard (June 2026 instrument).
What adverse events have studies of MOTS-c reported?
No study reporting adverse events from MOTS-c administration was found. Human studies in PubMed measure natural blood levels of MOTS-c (for example after exercise). Studies that give MOTS-c are in rodents and cells, and their abstracts do not report adverse events.
Is MOTS-c a peptide?
Yes. MOTS-c is a peptide of 16 amino acids.
Is MOTS-c a prescription medicine in Australia?
MOTS-c is not named in the Poisons Standard (June 2026 instrument). Peptides Collective sells it for laboratory research use only.
Is MOTS-c banned in sport?
WADA's 2026 Prohibited List prohibits MOTS-c at all times, under class S4.4.1.
What is the CAS number for MOTS-c?
The CAS number for MOTS-c is 1627580-64-6. Its PubChem CID is 146675088.
How long does an unopened MOTS-c vial keep?
A sealed vial of lyophilised powder keeps to the date on its label when stored frozen, dry and dark. Once reconstituted, keep the solution at 2 to 8 degrees Celsius and record the date on the label.
Does every MOTS-c batch have a certificate?
Yes. Every MOTS-c batch is tested by [lab] before it goes on sale, and the certificate is published under the batch number printed on the vial. The current batch certificate is [pending].
Where is MOTS-c shipped from?
Orders ship tracked from Western Australia. Orders placed before [cut-off] leave the same business day. Delivery estimates by state are on the shipping page.
What purity is the current MOTS-c batch?
The current MOTS-c batch certificate is [pending]. When it is published, it reports purity by HPLC to three decimal places and confirms identity by mass spectrometry.
Which solvent reconstitutes MOTS-c?
BAC Water (sterile water with 0.9% benzyl alcohol) is the usual laboratory solvent. Dilute acetic acid is an alternative for peptides that dissolve poorly in water. Record the solvent, volume and resulting concentration on the vial label.
Sources
- 1. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell metabolism, 2015. PMID 25738459.
- 2. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in endocrinology, 2023. PMID 36761202.
- 3. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. Journal of translational medicine, 2023. PMID 36670507.
- 4. Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. Journal of applied physiology (Bethesda, Md. : 1985), 2021. PMID 34351816.
- 5. PubChem CID 146675088. National Library of Medicine.
- 6. Poisons Standard, June 2026 instrument (F2026L00633). Federal Register of Legislation.
- 7. World Anti-Doping Code, 2026 Prohibited List. WADA.
