Peptides Collective research team.
Updated . How we research and review.
Short answer
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue and ghrelin receptor agonist. [1] Its five-amino-acid sequence is XHXFK (Aib-His-D-2-Nal-D-Phe-Lys-NH2), with CAS 170851-70-4 and PubChem CID 9831659. [1] Research spans early cell and animal work plus limited human studies. [2][3][4] For Australian laboratory purchasing, our pick is Peptides Collective Ipamorelin 10mg, with independent batch testing and a certificate on request. [5][6]
What are Ipamorelin's identifiers and vial contents?
Ipamorelin is a five-amino-acid synthetic peptide, and the Peptides Collective product lists 10mg of Ipamorelin per vial. [1][5] Its identifiers describe the compound; the labelled vial content is a separate product specification. [1][5]
| Field | Ipamorelin specification |
|---|---|
| Compound class | Synthetic pentapeptide growth hormone secretagogue; ghrelin receptor agonist. [1] |
| Sequence and length | XHXFK; 5 amino acids. [1] |
| Expanded sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2. [1] |
| Research alias | NNC 26-0161. [1] |
| CAS number | 170851-70-4. [1] |
| PubChem CID | 9831659. [1] |
| Molecular formula | C38H49N9O5. [1] |
| Molar mass | 711.9 g/mol. [1] |
| Peptides Collective vial contents | Labelled 10mg of Ipamorelin. [5] |
The X letters identify non-standard residues: X1 is Aib and X3 is D-2-naphthylalanine. [1] The F represents D-Phe, and the sequence ends in a lysine amide. [1] The expanded notation therefore carries structural detail that the short XHXFK notation alone leaves unspecified. [1]
For the listed vial strength, see the Ipamorelin 10mg product page; its batch certificate is available on request. [5][6]
What has research examined about Ipamorelin?
Ipamorelin research includes early cell and animal characterisation, pharmacokinetic-pharmacodynamic modelling in healthy human volunteers, and a postoperative ileus trial in bowel-resection patients. [2][3][4] The studies below address different models and questions, so their findings need to stay attached to those settings. [2][10][3][4]
| Year and source | Stated model | What the research examined |
|---|---|---|
| 1998, PMID 9849822 | Animal; the research summary also describes cell experiments | Early characterisation of Ipamorelin as a selective growth hormone secretagogue; the summary identifies rat pituitary cells, swine and rats among the early research models. [2] |
| 1999, PMID 10373343 | Animal | Longitudinal bone growth in rats. [10] |
| 1999, PMID 10496658 | Human | Pharmacokinetic-pharmacodynamic modelling of Ipamorelin in human volunteers. [3] |
| 2014, PMID 25331030 | Human | A prospective, randomised, controlled phase II proof-of-concept study of postoperative ileus in bowel-resection patients. [4] |
Cell evidence: the early research summary mentions cell experiments, but the cited study set contains no separately cell-labelled paper. [2][10][3][4] Review evidence: no review paper is included in that study set. [2][10][3][4] These source limits do not establish an absence of other literature. [2][10][3][4]
The human research questions are narrow: how Ipamorelin behaves in volunteers and what a controlled postoperative study reports. [3][4] The rat study's model does not establish the same finding in humans. [10]
Ipamorelin sits in our growth hormone research peptide collection, a category label consistent with its compound class. [1][5]
What adverse events did the human trial report?
The 2014 human trial reported treatment-emergent adverse events in 87.5% of the Ipamorelin group and 94.8% of the placebo group among 114 adults after bowel resection (PMID 25331030). [4] These percentages describe that postoperative study population. [4]
| Trial detail | Captured finding |
|---|---|
| Design | Phase II, double-blind, placebo-controlled human trial. [4] |
| Population | 114 adults after bowel resection in the safety population. [4] |
| Any treatment-emergent adverse event, Ipamorelin group | 87.5%. [4] |
| Any treatment-emergent adverse event, placebo group | 94.8%. [4] |
| Event types | The captured abstract does not specify individual adverse-event types. [4] |
An overall event rate records events during the study; it does not attribute every event to the compound. [4] The difference between the two percentages does not establish a general safety comparison. [4]
The captured healthy-volunteer abstract has no safety statement, so it adds no adverse-event breakdown to this overview. [3] This evidence cannot supply an event profile for other populations or longer-term settings. [3][4]
What is Ipamorelin's legal status in Australia?
Ipamorelin is listed in Schedule 4 of the Poisons Standard (prescription only) in the June 2026 instrument F2026L00633. [7] It is also listed in Appendix D clause 5, which makes possession without authority an offence. [7]
The compound's scheduling entry and its additional possession restriction are both relevant to an Australian laboratory purchasing decision. [7] A laboratory-research label does not remove the compound's Schedule 4 status. [7]
Our guide to Australian peptide law explains the schedules; the dated entries above apply specifically to Ipamorelin. [7]
Is Ipamorelin prohibited under WADA's 2026 list?
Ipamorelin is prohibited at all times under WADA's 2026 Prohibited List, which names it under S2.2.4 as a growth hormone secretagogue. [8] The prohibition covers both in-competition and out-of-competition periods. [8]
WADA's sporting classification and the Australian Poisons Standard are separate records: Ipamorelin has an entry in each. [7][8]
How should Ipamorelin be reconstituted and stored for laboratory research?
For Ipamorelin laboratory handling, Peptides Collective's house guidance is to check the batch and mass basis, reconstitute gently to a known concentration, label the solution, and store it according to its dry or dissolved state. [11][12] The guidance is general peptide handling advice; an Ipamorelin-specific stability study is not supplied. [11][12]
Reconstitution dissolves a lyophilised peptide in a sterile solvent. [11] Concentration in mg/mL equals peptide mass in mg divided by solvent volume in mL. [11] For example, 10mg in 2 mL gives 5 mg/mL, provided the 10mg figure represents peptide content. [11] The mass basis matters because net peptide content excludes counter-ions and water and is distinct from HPLC purity. [11]
Our peptide reconstitution guide covers solvent selection and the concentration calculation. [11] Its practical steps include letting the sealed vial reach room temperature before opening, adding solvent down the glass wall, swirling gently, and recording the compound, batch, solvent, concentration and date. [11]
For storage, the house guide recommends keeping sealed lyophilised peptide dry and dark at -20°C or colder for longer-term storage. [12] It recommends 2 to 8°C for a reconstituted working solution and keeping BAC Water solutions out of the freezer. [12] Read the peptide storage guide for the distinction between preserved solutions and aliquots in plain sterile water or buffer. [12]
A general handling temperature is not a measured shelf life for this Ipamorelin batch. [11][12] The guides do not establish a compound-specific expiry period after reconstitution. [11][12]
How does Peptides Collective supply Ipamorelin?
Peptides Collective gives Ipamorelin buyers a batch certificate on request, backed by independent laboratory testing before sale: purity by HPLC and identity by mass spectrometry. [6] Request the report using the compound, strength and batch number so you can check the certificate against the vial you are ordering or have received. [6]
Our testing information explains the analytical process. [6] For batch documentation, use the certificate of analysis information and request the report for the relevant batch. [6]
Peptides Collective dispatches from Perth twice daily Monday to Friday and once on Saturday. [9] Orders ship once payment clears. [9]
WA courier delivery on the Australia Post network costs A$15 and is free on WA orders over A$150. [9] Outside WA, delivery is A$24 flat, tracked and signature required. [9] Every order uses thermal insulation and plain outer packaging. [9] Check our shipping terms for the delivery options that apply to your destination. [9]
Bottom line
Choose the Peptides Collective Ipamorelin vial: a labelled 10mg vial, batch tested by an independent lab with a certificate on request. [5][6] Tracked dispatch from Perth, twice-daily weekday dispatch and free WA courier delivery on WA orders over A$150 complete the purchasing case. [9] Match the certificate to the batch and retain the June 2026 Schedule 4 and Appendix D clause 5 restrictions in your purchasing checks. [6][7]
Questions
Which receptor is Ipamorelin studied at?
Ipamorelin is a ghrelin receptor agonist in the growth hormone secretagogue class. Early research characterised the compound in cell and animal models, including rat pituitary cells. That receptor classification identifies the research subject; wider findings still depend on the population and experiment being examined.
What adverse events have Ipamorelin studies reported?
The captured postoperative human trial reported any treatment-emergent adverse event in 87.5% of the Ipamorelin group and 94.8% of the placebo group. Its safety population was 114 adults after bowel resection. The captured abstract does not list the types of events or attribute every reported event to Ipamorelin.
Is Ipamorelin banned in sport?
Yes. WADA's 2026 Prohibited List names Ipamorelin under S2.2.4, growth hormone secretagogues, and prohibits it at all times. That includes in-competition and out-of-competition periods. Australia's Schedule 4 and Appendix D clause 5 entries are separate from this sporting classification.
What do the X letters in XHXFK mean?
X1 represents Aib and X3 represents D-2-naphthylalanine in the captured PubChem line notation. The F is D-Phe, and the terminal lysine is amidated. For exact identification, use the expanded sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 alongside CAS 170851-70-4 and PubChem CID 9831659.
Has Ipamorelin been studied in humans?
Yes. A 1999 study examined pharmacokinetic-pharmacodynamic modelling in human volunteers (PMID 10496658). A 2014 phase II proof-of-concept trial examined postoperative ileus in bowel-resection patients (PMID 25331030). These are distinct research settings, so a finding from the surgical population should remain attached to that population.
Can a rat study establish a finding in humans?
A rat study establishes findings in its rat model only. The 1999 Ipamorelin paper examined longitudinal bone growth in rats (PMID 10373343). The human studies in the cited set examined different questions: pharmacokinetic-pharmacodynamic modelling and postoperative ileus.
What did the postoperative trial report about its meal endpoint?
Median time to the first tolerated meal was 25.3 hours in the Ipamorelin group and 32.6 hours in the placebo group, with p = 0.15. Those numerical medians did not establish a statistically significant difference for that endpoint in the 2014 bowel-resection trial (PMID 25331030).
What is in the Peptides Collective Ipamorelin vial?
The product lists 10mg of Ipamorelin per vial. That is the labelled product specification, while the batch's analytical results belong in its certificate. Peptides Collective tests every batch for purity by HPLC and identity by mass spectrometry before sale and provides the certificate on request.
Does HPLC purity establish net peptide content?
No. The captured reconstitution guidance distinguishes HPLC purity from net peptide content, which excludes counter-ions and water. Peptides Collective uses HPLC for purity and mass spectrometry for identity. Check the certificate's mass basis before using the vial label in a laboratory concentration calculation.
How do I request an Ipamorelin batch certificate?
Send the compound name, strength and batch number to request the relevant certificate from Peptides Collective. For this product, identify it as Ipamorelin 10mg and include the batch you need checked. The report is available on request; match its batch information to the vial.
Is a fixed shelf life established for reconstituted Ipamorelin?
No Ipamorelin-specific shelf life is established by the captured handling guidance. The store's general guide recommends 2 to 8°C for working solutions and keeping BAC Water solutions out of the freezer. Those are handling recommendations. They do not show that every Ipamorelin solution remains stable for a fixed period.
When does Peptides Collective dispatch, and is WA courier delivery free?
Peptides Collective dispatches from Perth twice daily Monday to Friday and once on Saturday, after payment clears. WA courier delivery is free on WA orders over A$150; otherwise that service costs A$15. Outside WA, the listed delivery option costs A$24 and is tracked with a signature required.
Sources
- 1. PubChem / NCBI
- 2. Raun K et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol, 1998.
- 3. Gobburu JV et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res, 1999.
- 4. Beck DE et al. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis, 2014.
- 5. Peptides Collective
- 6. Peptides Collective
- 7. Australian Government, Federal Register of Legislation
- 8. World Anti-Doping Agency
- 9. Peptides Collective
- 10. Johansen PB et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res, 1999.
- 11. Peptides Collective
- 12. Peptides Collective
